姓名： 彭海生 博士后 硕士生导师
职称职务：教授 best365网页版登录教师教学发展中心主任，基础医学部专任教师
荣誉：曾获大庆市新长征火炬突击手、大庆市青年科技奖、大庆市优秀科技工作者、哈医大优秀教师、哈医大优秀党员等荣誉称号。
社会兼职：现为世界医药联合会理事/中药药剂专业委员会理事、医药高等教育创新实验教材建设委员会副主任委员、黑龙江省生物医学工程协会理事、大庆市入选高端人库专家；Pharmacologia及中国医药导报等杂志编委; 为ACS nano等30余个SCI杂志审稿专家。为国家自然基金委员会函评专家、中华医学会奖评审专家、教育部硕士论文评审专家、教育部高校自然科学成果奖评审专家、北京市自然基金评审专家、京津冀联合基金评审专家、广西重大仪器设备专项评审专家、黑龙江重大项目评审专家及哈商大硕士研究生导师。
研究方向：生物材料合成与纳米靶向制剂机理研究
主讲课程：《药理学》、《药剂学》、《分子药剂学》
发表代表性论文：
1. Haisheng Peng*, Man Zhao, Xiaoying Liu, Tianjian Tong, Wenyuan Zhang, Chen Gong, Ratul Chowdhury, and Qun Wang. Biomimetic materials to fabricate artiffcial cells. Chemical Reviews. 2024. doi: 10.1021/acs.chemrev.4c00241.
2. Haisheng Peng, Bo Han, Tianjian Tong, Xin Jin, Yanbo Peng, Meitong Guo, Bian Li, Jiaxin Ding, Qingfei Kong, Qun Wang. 3D printing processes in precise drug delivery for personalized medicine. Biofabrication. 2024，16(3):10.1088/1758 -5090/ ad3a14.
3. Yue Hao, Yinchun Su, Yifan He, Wenyuan Zhang, Yang Liu, Yu Guo, Xingfan Chen, Chunhan Liu, Siyu Han, Buyi Wang, Yushuang Liu, Wei Zhao, Lili Mu, Jinghua Wang, Haisheng Peng*, Junwei Han*, Qingfei Kong*. Impaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model J Neuroinflammation. 2024, 21(1):10.
4. Dan Su, Zhong Chen, Xiaobin An, Junkai Yang, Jinan Yang, Xuqiao Wang, Yang Qu, Chen Gong, Yani Chai, Xiaoying Liu, Wei Cheng, Dongyang Wang, Yan Wu, Jing Ma, Xinyue Zhao, Qin Wang, Yun Xu*, Haisheng Peng*, Jing Ai* MicroRNA-195 liposomes for therapy of Alzheimer's disease J Control Release. 2024, 365: 583-601
5. Yuyan Guo, Shuang Shao, Ruinan Gu, Xiubo Hu, Man Zhao, Yanbo Peng, Wenyuan Zhang, Beining Zhang, Jiaxin Ding, Na Wang, Haisheng Peng*, and Jinxia Han* Application of nanomaterials in early diagnosis of cancer. Nanotechnology Reviews 2023; 12: 20230116.
6. Bo Yang*, Yongqing Mao, Yanjun Zhang, Yue Hao, Meitong Guo, Bian Li, Haisheng Peng* HA-Coated PLGA Nanoparticles Loaded with Apigenin for Colon Cancer with High Expression of CD44 Molecules. 2023, 28(22): 7565.
7. Jinxia Han, Yanfang Zhang, Haisheng Peng* Fucoxanthin inhibits cardiac fibroblast transdifferentiation by alleviating oxidative stress through downregulation of BRD4 PLoS One. 2023, 18(9): e0291469.
8. Haisheng Peng, Jiahe Wang, Jiayu Chen, Yanbo Peng, Xiaoxian Wang, Ying Chen, David L Kaplan, Qun Wang Challenges and opportunities in delivering oral peptides and proteins Expert Opin Drug Deliv. 2023, 20(10): 1349-1369.
9. Shengnan Xu, Rao Wei, Zhong Chen, Peng Ma, Guifen Qiang, Haisheng Peng* and Hai-Yu Hu* Lipid Droplets Formation and Dynamics: Tracking by Time-resolved Fluorescence Imaging Mater. Chem. Front., 2022, 6, 3691-3697
10.Wenyuan Zhang†, Man Zhao†, Yali Gao†, Xu Cheng, Xiaoying Liu, Shukun Tang, Yanbo Peng, Na Wang, Dandan Hu, Haisheng Peng*, Jinqiu Zhang*, and Qun Wang* Dandan Hu, Jinqiu Zhang*, Haisheng Peng*, and Qun Wang*. Biomimetic erythrocytes engineered drug delivery for cancer therapy. Chemical engineering journal. 2022, 433: 133498.
11.Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng*, and Changmei Zhang*. Design and evaluation of Glutathione responsive glycosylated comptothecin nanosupramolecular prodrug. Drug Delivery. 2021;28(1):1903-1914
12.Shukun Tang†, Zahra Davoud†, Guangtian Wang†, Zihao Xu, Tanzeel Rehman, Aleksander Prominski, Bozhi Tian, Kaitlin M. Bratlie, Haisheng Peng*, and Qun Wang*. Soft Materials as Biological and Artificial Membranes. Chemical society review. 2021, 2021, 50(22): 12679-12701.
13.Wenhua Li, Xiaoying Liu, Xu Cheng, Wenyuan Zhang, Chen Gong, Chuya Gao, Haisheng Peng, Bo Yang*, Shukun Tang*, Haiquan Tao*. Effect of Malt-PEG-Abz@RSL3 micelles on HepG2 cells based on NADPH depletion and GPX4 inhibition in ferroptosis. Journal of Drug Target. 2021, 11; 1-11.
14.Liwang Shi1, Jinqiu Zhang1, Man Zhao1, Shukun Tang, Xu Cheng, Wenyuan Zhang, Wenhua Li, Xiaoying Liu, Haisheng Peng*, Qun Wang* Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery. Nanoscale. 2021; 13(24): 10748-10764
15. Ren YC, Yuan BC, Hou SH, Sui YL, Yang TH, Lv ML, Zhou YL, Yu H, Li S, Peng HS*, Chang ND*, Liu Y*. Delivery of RGD-modified liposome for targeted colorectal carcinoma therapy and study of its autophagy mechanism. Journal of Drug Target. 2021; 29(8):863-874.
16.Liao JH1, Peng HS1, Liu C, Li D, Yin YH, Lu B, Zheng H*, Wang Q*. Dual pH-responsive-charge-reversal micelle platform for enhanced anticancer therapy. Materials Science and Engineering: C. 2021, 111527.
17.Li MH‡, Tang XF‡, Liu XY, Cui XY, Lian MM, Zhao M, Peng HS*, Han XJ*. Targeted miR-21 loaded liposomes for acute myocardial infarction. Journal of Materials Chemistry B 2020. 8.10384-10391
18.Chen Z, Peng HS*, Zhang CM*. Advances in kidney-targeted drug delivery systems. International Journal of Pharmaceutics. 2020, 587: 119679
19.Chen Z, Li WH, Shi LW, Jiang L, Li MH, Zhang CM*, and Peng HS*. Kidney Targeted Astaxanthin Natural Antioxidant Nanosystem for Diabetic Nephropathy Therapy. European Journal of Pharmaceutics and Biopharmaceutics. 2020, 156: 143-154
20.Wang N1, Zhang WY1, Hu DD1, Jiang L, Liu XY, Tang SK, Zhou XG, Liu T, Tang XF, Chai YQ, Li MH, Peng HS*, and Du ZM*. ‘Prodrug-like’ acetylmannosamine modified liposomes loaded with arsenic trioxide for the treatment of orthotopic glioma in mice. Journal of Pharmaceutical Sciences. 2020, 109(9): 2861-2873.
21.Zhang CM, Chen Z, Li WH, Liu XY, Tang SK, Jiang L, Li MH, Peng HS*, and Lian MM*. Influences of Different Sugar Ligands on Targeted Delivery of Liposomes. Journal of Drug Targeting. 2020, 28(35): 1-28.
22.Yang B1, Jiang JQ1, Jiang L1, Zheng PY, Wang FL, Zhou Y, Chen Z, Li MH, Lian MM, Tang SK, Liu XY*, Peng HS*, and Wang Q*. Chitosan mediated solid lipid nanoparticles for enhanced liver delivery of zedoary turmeric oil in vivo. International Journal of Biological Macromolecules. 2020, 149(15): 108-115.
23.Jiang L1, Wang JH1, Jiang JQ1, Zhang CM, Zhao M, Chen Z, Wang N, Hu DD, Liu XY, Peng HS*, Lian MM*. Sonodynamic Therapy in Atherosclerosis by Curcumin Nanosuspensions: Preparation design, Efficacy Evaluation, and Mechanisms Analysis. European Journal of Pharmaceutics and Biopharmaceutics. 2020,146: 101-110.
24.Liao JH, Peng HS, Wei X, Song YJ, Liu C, Li D, Yin YH, Xiong X, Zheng H*, Wang Q*. A bio-responsive 6-mercaptopurine/doxorubicin based “Click Chemistry” polymeric prodrug for cancer therapy. Materials Science and Engineering: C. 2020,108: 10461
25.Liu XY1, Tang SK1, Liu YC1, Hu DD, Zhang CM, Zhang WY, Chai YQ, Tang XF, Jiang L, Gong C, Peng HS*, Li MH*. Targeting Regulation of Dually Modified Liposomes by Polyethylene Glycol Length of Vesicle Surface. Journal of Biomedical Nanotechnology. 2019; 12(15): 2413-2427
26.Zhang DP, Lian MM*, Liu J, Tang SK, Liu GZ, Ma CF, Meng QW, Peng HS*, Zhu DL. Preparation of O-Protected Cyanohydrins by Aerobic Oxidation of α-Substituted Malononitriles in the Presence of Diarylphosphine Oxides. Organic Letters. 2019, 8(21): 2597-2601
27. Poovaiah N1, Davoudi Z1, Peng HS1, Schlichtmann B, Mallapragada SK, Narasimhan B. and Wang Q.* Treatment of Neurodegenerative Disorders through the Blood-brain Barrier using Nanocarriers. Nanoscale. 2018, 10, 16962-16983
28. Liu DM, Tang SK, Wang GT, Li MH, Liu XY, Tao HQ, Ren YC, Jiang CL*, Peng HS*, and Lian MM*. The Influences of Dynamic Transport of GLUT1 on the Distribution of Mannosylated Liposomes in Transient Ischemia Reperfusion Mice Brain. J. Biomed Nanotech. 2017; 13(17): 638-654.
主持或参与课题：
绍兴文理学院-浙江大学绍兴研究院联合基金，靶向糖基脂质体克服血中脱靶治疗脑胶质瘤的研究，2024.01-2024.12，在研，主持，30万元
企业委托项目，珍珠粉纳米制剂研究，2023.09-2024.12，在研，主持，20万元
3.企业委托项目，乳核內消颗粒工艺复核研究，2021.9-2021.11，结题，主持，1.2万元
4. 医院委托项目， 大庆市中医院院内制剂备案研究，2019.8-2021.9，结题，主持 168万
5. 企业委托项目，抗感泡腾片的放大工艺研究，2018/9-2019/3，结题，主持45万
6. 国家自然基金面上项目，糖/抗体/肽靶向纳米载体的表面(层)物质基础对缺血心肌miR-1/MMP9/Glut1摄取调控机制，81671814，2017/1-2018/12，结题，主持 25万
7. 黑龙江自然基金重点项目，微环境响应性心靶向纳米复合体的构建与疗效研究，ZD2016013，2016/7-2019/7，结题，主持 20万
8. 哈尔滨医科大学于维汉院士杰出青年培养基金，心肌靶向制剂的设计与相关机理研究，2015/1-2017/12，结题，主持 30万
9. 哈尔滨医科大学（大庆）优秀硕导基金，心肌靶向制剂研究，DSJJ2015004，2015/1-2017/12，结题，主持 （Postgraduate Tutor Foundation of Harbin Medical University-Daqing） 3万
10. 哈尔滨医科大学研究生创新基金，YJSCX2015-60HYD，光敏脂质体对心肌缺血的疗效研究，2015/7-2017/7，结题，指导 0.5万
11. 黑龙江省教育厅项目，12541348，新型脑区靶向性脂质体的分布调控及机制研究，2014/1- 2016/12，结题，主持 2.5万
12. 国家自然青年科学基金项目，81402865，抗体修饰的miR-21脂质体靶向急性缺血心肌的研究，2015/1-2017/12，结题，指导 23万
编写教材：
1.《中药药剂学》科学出版社 十四五规划教材 编委
2..《药剂学》中国医药科技出版社 十四五规划教材 编委
3.《药剂学实验》（双语）中国医药科技出版社 副主编
4.《药剂学实验》 中国医药科技出版社 主编
5. 《药物制剂技术》 科学出版社 参编
专利：
一种载有正电聚合物/miR-195复合物的脑靶向纳米脂质体及其制备方法与应用 （202010121226.2）
2. 糖-聚乙二醇-DSPE偶联化合物及其制备方法和应用（201811062535.68）
3. 热激活延迟荧光（TADF）纳米探针及其制备方法和在生物成像中的应用（201811325113.3）
4. 一种乙酰化糖酯-聚乙二醇磷脂酰乙醇胺共轭物及其制备方法与应用 （201810301839.7）
5. 一种心脑双靶向脂质体及其制备方法和应用 （201810299429.3）
6. 一种抗心肌肌钙蛋白抗体修饰并载有miR-21的脂质体及其制备方法和应用（20181098620.X）
7. 一种基于PPV病毒样颗粒的纳米递药系统及其制备方法和应用 （201510593848.4）
